In Sevilla, they face a side who are coming into this game at the back of a humiliating 0-4 defeat to Chelsea at home in the Champions League.
It will be a game to watch and for Zinedine Zidane, it will be a game that could play a part in deciding his future as the manager of the club.
Here, we take a look at some of the contests likely to become the key moments of the game on Saturday:
Lucas Ocampos vs Ferland Mendy
The Argentina international will rock shoulders with Ferland Mendy over the weekend and will hope to get the better of him. Mendy has always been a nightmare to play against in league but Ocampos will be looking to breaking that duck and making an impact in the game.
Jesus Navas vs Vinicius Junior
Both defensively and attacking wise, Jesus Navas has improved on his game and his crosses going forward will be a headache for the away side. However, in defence he will face Vinicius Junior who is at the moment not in the best of forms. The game will be a perfect time for the youngster to regain momentum and get going once again.
Ivan Rakitic vs Luka Modric
Two of the best midfielders in La Liga will come face to face on Saturday with a lot to play for in this game. Rakitić has been involved in two goals already for his side this term while Modric has been on the scoresheet once. Their creativity will be put to test when they feature at the Ramon Sanchez Pizjuan Stadium.
Yassine Bounou vs Thibaut Courtois
Bono has missed Sevilla’s last two games in the league through injury but he is expected to return in goal for Julen Lopetegui’s men on Saturday. He has two clean sheets in six games so far and the weekend will be another chance for him to add up.
Thibaut Courtois on the other hand has kept three clean sheets in the 10 league games he has feature in this campaign and is yet to keep any in his last six league games. He will look to make vital saves against the Seville-based club on Saturday.